Xylitol

Xylitol is a naturally occurring sugar substitute that is often used medicinally to prevent dental cavities, treat dry mouth, and prevent ear infections in young children. It appears to work by inhibiting bacterial growth and decreasing the level of certain cavity-causing bacteria in saliva and dental plaque. Although it is a "natural" product, xylitol can still cause side effects, such as diarrhea and gas.

What Is Xylitol?

Xylitol is a sugar substitute. It is a "natural" product (not an artificial sweetener) found in various plants such as raspberries and strawberries. Most commercial xylitol is made from birch trees. It is often used in sugar-free candies and gums. Medicinally, xylitol is claimed to be helpful for preventing dental cavities, treating dry mouth, and preventing ear infections in young children.
 
(Click Xylitol Benefits for more information on possible uses.)
 

How Does It Work?

Xylitol is a sugar alcohol. It does not contain any carbohydrates, but it is not calorie-free (although it contains fewer calories than sugar). It is useful as a sugar substitute for people with diabetes because it does not cause the significant rise in blood glucose (blood sugar) caused by real sugar. Nor does it seem to affect insulin levels in humans.
 
Xylitol may prevent dental cavities in several ways. It seems to decrease the level of certain cavity-causing bacteria in the saliva and dental plaque. It also decreases the acid production by the bacteria, decreases the stickiness of the bacteria, increases saliva flow, and increases calcium and phosphate in the saliva. All these actions can help to prevent cavities. Interestingly, habitually chewing gum with this sugar substitute can help mothers reduce the chance of transmitting cavity-causing bacteria to their young infants.
 
Xylitol may also inhibit bacterial growth (since most bacteria cannot use it as a source of energy), which might be why it may be useful for preventing ear infections.
 

Is Xylitol Effective?

This sugar substitute is indeed effective for decreasing dental cavities when used properly. Early evidence suggests that it might also help prevent ear infections in young children, although more research is necessary to confirm these findings.
 
(Click Does Xylitol Work? for more information.)
 

Dosing Information

There are no clearly established dosing guidelines for xylitol, although some information about dosing is available based on clinical studies and practical experience (click Xylitol Dosage for more information).
 

Are There Side Effects?

Although it is a "natural" product, xylitol can still cause side effects. Some of the more commonly reported side effects (especially with high doses) include:
 
(Click Xylitol Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
 

Drug Interactions

This sugar substitute is not known to interact with any medications (see Xylitol Drug Interactions).
 

Are There Safety Concerns With Xylitol?

Xylitol appears to be a safe sugar substitute. Although very high doses have caused problems in laboratory animals, similar problems have not been seen in humans. However, it is a good idea to check with your healthcare provider before taking any sugar substitute if you:
 
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
(Click Is Xylitol Safe? for more information, including any available warnings and precautions.)
 

What If I Take an Overdose?

Overconsumption is likely to cause diarrhea and gas. Very high doses given by IV have been shown to cause a few different problems. If you think you may have taken too much xylitol, seek immediate medical attention.
 
(Click Xylitol Overdose for more information.)
 

How Should Xylitol Be Stored?

It is essential to keep all xylitol products away from pets, as they can cause dangerously low blood sugar, liver failure, and death in dogs.
 
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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