Cyclosporine
Taking
Xenical and cyclosporine at the same time may decrease the absorption of cyclosporine into your body, perhaps making it less effective. If you take cyclosporine, you should check with your healthcare provider before taking Xenical. Your healthcare provider may recommend that you take cyclosporine at least two hours before or after Xenical in order to avoid this interaction.
Diabetes Medications
Often, when people with
diabetes lose weight, their
diabetes medications need to be adjusted (typically with lower dosages). In studies, many people who took Xenical were able to decrease (or even stop) their diabetes medications. Make sure that your healthcare provider is aware of your plans for weight loss with Xenical, as you may need to be monitored more closely. As you lose weight, your healthcare provider may need to decrease the dose of your diabetes medications accordingly.
Thyroid Medications
Low thyroid function (
hypothyroidism) has been reported in people taking Xenical and a thyroid medication. While you are taking Xenical, your thyroid function should be monitored, and your healthcare provider may need to adjust the dose of your thyroid medication.
Additionally, be sure to take Xenical and thyroid medications at least four hours apart, as this may reduce the chance of a drug interaction.
Vitamins
Xenical can decrease the absorption of certain vitamins from your diet, possibly leading to a vitamin deficiency. In particular, this interaction affects fat-soluble vitamins, such as
vitamin A, vitamin D,
vitamin E, and beta-carotene. You should take a multivitamin once a day (at least two hours before or after Xenical) while you are on the drug. Bedtime is usually a good time to take a multivitamin.
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