Taking Xenical and cyclosporine at the same time may decrease the absorption of cyclosporine into your body, perhaps making it less effective. If you take cyclosporine, you should check with your healthcare provider before taking Xenical. Your healthcare provider may recommend that you take cyclosporine at least two hours before or after Xenical in order to avoid this interaction.

 

Often, when people with diabetes lose weight, their diabetes medications need to be adjusted (typically with lower dosages). In studies, many people who took Xenical were able to decrease (or even stop) their diabetes medications. Make sure that your healthcare provider is aware of your plans for weight loss with Xenical, as you may need to be monitored more closely. As you lose weight, your healthcare provider may need to decrease the dose of your diabetes medications accordingly.

 

Weight loss can affect how much thyroid medication you need. If you take thyroid medication, make sure to tell your healthcare provider about your weight loss plans. He or she may choose to monitor you more closely while you are taking Xenical, adjusting the dose of your thyroid medications if necessary.

 

Xenical can decrease the absorption of certain vitamins from your diet, possibly leading to a vitamin deficiency. In particular, this interaction affects fat-soluble vitamins, such as vitamin A, vitamin D, vitamin E, and beta-carotene. You should take a multivitamin once a day (at least two hours before or after Xenical) while you are on the drug. Bedtime is usually a good time to take a multivitamin.

 

Xenical can affect the level of vitamin K in your body, which affects the way you respond to warfarin. Your healthcare provider may need to monitor you more closely and adjust your warfarin dosage as necessary if you are taking these drugs at the same time.