Xenical Drug Interactions

Diabetes Medications
Often, when people with diabetes lose weight, their diabetes medications need to be adjusted (typically with lower dosages). In studies, many people who took Xenical were able to decrease (or even stop) their diabetes medications. Make sure that your healthcare provider is aware of your plans for weight loss with Xenical, as you may need to be monitored more closely. As you lose weight, your healthcare provider may need to decrease the dose of your diabetes medications accordingly.
Seizure Medications
There have been reports of seizures occurring in people on seizure medications who took Xenical. People who take these products together should be aware of this possibility and should watch for any increase in seizure frequency or severity.
Thyroid Medications
Low thyroid function (hypothyroidism) has been reported in people taking Xenical and a thyroid medication. While you are taking Xenical, your thyroid function should be monitored, and your healthcare provider may need to adjust the dose of your thyroid medication.
In addition, be sure to take Xenical and thyroid medications at least four hours apart, as this may reduce the chance of a drug interaction.
Xenical can decrease the absorption of certain vitamins from your diet, possibly leading to a vitamin deficiency. In particular, this interaction affects fat-soluble vitamins, such as vitamin A, vitamin D, vitamin E, and beta-carotene. You should take a multivitamin once a day (at least two hours before or after Xenical) while you are on the drug. Bedtime is usually a good time to take a multivitamin.
Xenical can affect the level of vitamin K in your body, which affects the way you respond to warfarin. Your healthcare provider may need to monitor you more closely and adjust your warfarin dosage as necessary if you are taking these drugs at the same time.
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