Phentermine Drug Interactions

Phentermine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when phentermine is combined with any of the drugs listed above.
In general, it is usually recommended for people to avoid drinking alcohol while taking phentermine.
Diabetes Medications
Because you may eat less while taking phentermine (because the drug is an appetite suppressant), your healthcare provider may need to decrease the dose of your diabetes medications. This is particularly important for people who take insulin.
Phentermine may make guanethidine less effective at lowering blood pressure. If you take guanethidine, make sure your healthcare provider knows you are also taking phentermine.
Monoamine Oxidase Inhibitors (MAOIs)
Taking phentermine and MAO inhibitors together can cause life-threatening side effects, such as very high blood pressure. Do not take phentermine if you are currently taking an MAOI or have taken an MAOI within the past 14 days.
Other Weight-Loss Medications
Phentermine has not been adequately studied in combination with any other obesity medications. It is not recommended that phentermine be combined with other weight-loss medications.
Sodium Bicarbonate
Sodium bicarbonate (when taken as a medication, not in normal food use) can increase the level of phentermine in your blood, increasing your risk of phentermine side effects. Check with your healthcare provider before taking these medications together.
Tricyclic Antidepressants
Taking phentermine with a tricyclic antidepressant can increase the risk of dangerous side effects from either medication. Check with your healthcare provider before combining phentermine with a tricyclic antidepressant.
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