Phentermine Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
phentermine is combined with any of the drugs listed above.
Alcohol
In general, it is usually recommended for people to avoid drinking alcohol while taking phentermine.
Diabetes Medications
Because you may eat less while taking phentermine (because the drug is an appetite suppressant), your healthcare provider may need to decrease the dose of your
diabetes medications. This is particularly important for people who take insulin.
Monoamine Oxidase Inhibitors (MAOIs)
Taking phentermine and MOA inhibitors together can cause life-threatening side effects, such as very
high blood pressure. Do not take phentermine if you have taken an MAOI within the past 14 days.
Other Weight-Loss Medications
Phentermine has not been adequately studied in combination with any other obesity medications. It is not recommended that phentermine be combined with other weight-loss medications.
Sodium Bicarbonate
Sodium bicarbonate (when taken as a medication, not in normal food use) can increase the level of phentermine in your blood, increasing your risk of
phentermine side effects. Check with your healthcare provider before taking these medications together.
Tricyclic Antidepressants
Taking phentermine with a
tricyclic antidepressant can increase the risk of dangerous side effects from either medication. Check with your healthcare provider before combining phentermine with a tricyclic
antidepressant.
Tromethamine (THAM)
Tromethamine can increase the level of phentermine in your blood, increasing the risk of side effects. Talk with your healthcare provider before taking tromethamine and phentermine together.
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