Drug Interactions With Orlistat

If certain medications are taken together, there is a possibility of drug interactions. With orlistat, taking it with warfarin, diabetes medications, or cyclosporine can affect the level of medications in your blood and change their effectiveness as a result. To avoid drug interactions with orlistat, tell your healthcare provider about your weight loss plans. He or she may decide to monitor you more closely or adjust your dosages.

 

An Introduction to Drug Interactions With Orlistat

Orlistat (Alli™, Xenical®) can potentially interact with a few other medications. Some of the medicines that may lead to orlistat drug interactions include:
 
 
  • Vitamins
     
  • Warfarin (Coumadin®, Jantoven®).
 

Orlistat Interactions Explained

The following sections explain in detail the interactions that can occur when orlistat is combined with any of the drugs listed above.
 
Amiodarone
Orlistat may interfere with the absorption of amiodarone from your digestive tract, perhaps making it less effective. Talk to your healthcare provider before taking these drugs together, as you may need to be monitored more closely.
(Drug Interactions With Orlistat Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;