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Clinical studies have shown that Qsymia can cause headaches, constipation, insomnia, and other side effects. While these common reactions tend to be mild and easy to treat, there are some potentially serious problems that may require immediate medical treatment. Let your healthcare provider know right away if you experience complications like changes in vision, suicidal thoughts, or an abnormal heartbeat.
As with any medicine, Qsymia® (phentermine and topiramate) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in many cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Qsymia. Your healthcare provider can discuss a more complete list with you.)
Qsymia has been studied thoroughly in clinical trials. In these studies, one group of people received the real medication, while another group was given a placebo (a "sugar pill" with no active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo.
In clinical studies, the most common side effects of Qsymia included:
- Unusual sensations, such as tingling, numbness, or pricking, especially of the hands, feet, or face -- in up to 19.9 percent of people
- Dry mouth -- up to 19.1 percent
- Constipation -- up to 16.1 percent
- Upper respiratory tract infection -- up to 15.8 percent
- The common cold -- up to 12.5 percent
- Headache -- up to 10.6 percent
- Changes in how things taste -- up to 9.4 percent
- Insomnia -- up to 9.4 percent
- Dizziness -- up to 8.6 percent.
- Inflammation or infection of the sinuses -- up to 7.8 percent.
Other common side effects, occurring in 2 percent to 7.5 percent of people, included:
- Influenza (the flu)
- Back pain
- Blurred vision
- Urinary tract infection
- Symptoms of the stomach flu
- Reduced sense of touch
- Hair loss
- Difficulty with attention
- Sore throat
- Arm or leg pain
- Muscle pain or spasms
- Heartburn, indigestion, or reflux
- Dry eyes
- Eye pain
- Feelings of a pounding, racing, or "skipped" heartbeat
- Decreased appetite
- Low blood potassium levels
- Chest discomfort
- Painful menstrual periods in women
- Neck pain.