Weight Loss Home > Didrex

Didrex is a weight loss drug that is prescribed for short-term use only and is meant to be used with an appropriate diet. It works by suppressing the appetite and possibly increasing the metabolism. Didrex comes in tablet form and is typically taken one to three times a day. Possible side effects include insomnia, sweating, and headaches.

What Is Didrex?

Didrex® (benzphetamine hydrochloride) is a prescription weight loss medication approved for short-term use only. It should be used in conjunction with an appropriate diet.
(Click Didrex Uses for more information, including possible off-label uses.)

Who Makes It?

Didrex is made by Pfizer, Inc.

How Does It Work?

Didrex works by suppressing the appetite, and it may also increase the metabolism.

Effects of Didrex

Only very short studies have evaluated the effectiveness of Didrex. In these studies, people taking this medication lost more weight than those not taking it, but the difference was small (only a fraction of a pound more per week for the people taking Didrex). Studies also suggest that the effects of the medication on weight loss decreased after the first few weeks.

When and How to Take It

Some general considerations for when and how to take Didrex include the following:
  • The medication comes in tablet form. It is taken by mouth one to three times daily.
  • You can take Didrex on an empty stomach or with food. If the medication bothers your stomach, try taking it with food.
  • Didrex should be combined with an appropriate diet. It is not meant to be used without dieting.
  • Do not take this medication more often or at higher doses than prescribed, as this can lead to addiction or dependence.
  • For the medication to work properly, it must be taken as prescribed.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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