Guarana Interactions

Other Stimulants
Use caution when combining guarana with any other stimulant. Guarana contains a large amount of caffeine, which can be dangerous when taken with other stimulants.
 
Cimetidine
Cimetidine may increase the level of caffeine (the active ingredient in guarana) in your blood, perhaps increasing the risk of guarana side effects. Check with your healthcare provider before taking these substances together.
 
Clozapine
For some people, caffeine (the primary component of guarana) can make psychotic symptoms worse. In addition, there is some evidence that caffeine may increase the level of clozapine in your blood, which may lead to dangerous side effects. Check with your healthcare provider before combining guarana with clozapine.
 
Diabetes Medications
There is some evidence that caffeine (the primary component of guarana) may affect blood sugar, although it is not clear how important this interaction may be. You may need to monitor your blood sugar more closely while taking guarana.
 
Fluoroquinolone Antibiotics
Guarana contains a significant amount of caffeine, and fluoroquinolone antibiotics can increase the level of caffeine in your blood, perhaps increasing the risk of side effects. Check with your healthcare provider before combining these two substances.
 
Fluvoxamine
Fluvoxamine may increase the level of caffeine (the active ingredient of guarana) in your blood, possibly increasing your risk of guarana side effects. Ask your healthcare provider before taking fluvoxamine and guarana together.
 
Mexiletine
Mexiletine may increase the level of caffeine (the active ingredient of guarana) in the blood, which may increase the risk of side effects. Talk with your healthcare provider before combining these two substances.
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