5-HTP Side Effects

Heartburn, diarrhea, and nausea are among the possible side effects of 5-HTP. Because 5-HTP is a supplement, large clinical studies have not been done to determine more information on possible side effects (such as rare side effects). However, serious 5-HTP side effects are certainly possible. Contact your healthcare provider if you experience severe muscle pain, seizures, or signs of an allergic reaction while taking the supplement.

Does 5-HTP Cause Side Effects?

As with any medication or supplement, side effects are possible with 5-HTP (5-hydroxytryptophan). However, as with most supplements, little information is available about 5-HTP side effects, as large, adequately designed clinical studies have not been performed. Large studies are important in order to find any rare side effects.
 
(This article covers many, but not all, of the possible side effects with 5-HTP. Your healthcare provider can discuss a more complete list of 5-HTP side effects with you.)
 

Possible Side Effects With 5-HTP

Many of the reported  side effects with 5-HTP are related to the digestive system, and may include:
 
  • Heartburn or indigestion
  • Abdominal pain (stomach pain)
  • Diarrhea
  • Belching
  • Nausea or vomiting
  • Loss of appetite.
     

5-HTP Side Effects to Report

There are a number of less common, but potentially serious side effects of 5-HTP that you should report to your healthcare provider. These include but are not limited to:
 
  • Severe muscle pain, which is an early sign of eosinophilia myalgia syndrome (EMS), which may be associated with 5-HTP use
  • Seizures
  • Signs of an allergic reaction, such as:
 
    • Itching
    • Hives
    • A rash
    • Wheezing
    • Difficulty breathing
    • Swelling of the mouth or throat.
 
(5-HTP Side Effects Continued: Page 2)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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